Lung Transplant Research Lab
Experimental focus
Our focus is on the study of the basic immunological processes that operate after lung transplantation. In particular, we study the alloreactive and autoreactive response against the lung allograft at both the cellular and molecular levels, with special emphasis on humoral activation and immunomodulation.
The laboratory's close contact with one of the world's most active lung transplant centers ensures an excellent environment for conducting translational research to improve diagnostic capabilities and therapeutic strategies after lung transplantation.
Clinical focus
We participate in the development of novel immunosuppressive protocols and investigate their mechanisms of action to promote immunomodulation and transplant tolerance. The second major clinical focus of our research group is ex vivo lung perfusion (EVLP). In this context, the main concern of our group is to develop an efficient and stable platform for prolonged allograft assessment and conditioning.
- Investigating the effects of different induction immunosuppression agents on the host humoral immunity after lung transplantation – Austrian Fund of Science
- ECP for subclinical AMR after lung transplantation: a RCT – Austrian Fund of Science
- EXTRA: Innovative Applications of Extracorporeal Photopheresis in Solid Organ Transplantation. HORIZON-MSCA-2022-DN-01
- Analysis of the phenotype of regulatory B cells and IL-10 expression in the peripheral blood of lung transplant patients.
- Evaluating the addition of hemodiafiltration to ex-vivo lung perfusion – impact on the regeneration of marginal donor lungs: a prospective randomized pilot study
- A low-dose immunosuppression protocol in lung transplantation: a prospective randomized study – Austrian Fund of Science
- Extracorporeal photoimmune therapy (ECP) after lung transplantation - Mallinckrodt Pharmaceuticals