Research in the field of transplantation at the Medical University of Vienna is multi-disciplinary, spanning the entire spectrum of experimental, translational and clinical studies. Bench-to-bedside – and back again – is a cardinal feature and a long-standing reality of transplantation research. Numerous research groups in all disciplines closely linked to the high volume clinical transplant programs provide an excellent environment for translating scientific findings into therapeutic interventions for patients.
Research in the field of transplantation comprises three closely interlinked areas:
The understanding of basic immunologic mechanisms is the prerequisite for the development of new diagnostic and therapeutic interventions in the field of transplantation. Research topics include molecular cell biology at the level of transcription factors, in vitro studies investigating signaling pathways and cellular interactions and preclinical animal models for the development of tolerance strategies.
The goal of translational science is the efficient translation of results from experimental studies into clinical practice and thus direct benefit for the patient. This includes the classical bench-to-bedside approach: experimental in vitro data are verified in preclinical animal models before they can be investigated in clinical trials. Research topics include development of treatment protocols for humoral sensitization and rejection and the search for biomarkers by “omics” technologies and methodological research including statistical methods for estimation of molecular and clinical parameters of transplant rejection.
As a busy transplant center the Medical University of Vienna has a long track record in both industry-sponsored and in investigator-driven phase II, III and IV trials. An experienced staff of study nurses and coordinators assures high recruitment numbers and strict adherence to ICH-GCP standards. This environment allows swift translation of relevant findings to the clinical setting.